Uneven ground subsidence is one of the important factors affecting the operational safety of underground pipelines. In this study, a numerical simulation method was employed to quantitatively analyze the variation law and characteristics of settlement and Mises stress of underground pipelines with different buried depths, pipe diameters and pipe materials under conditions of active fault creep subsidence, crossing construction subsidence and shallow groundwater extraction subsidence. The research results indicate that active fault creep subsidence has the most significant influence on the settlement deformation and stress of underground pipelines, followed by shallow groundwater extraction subsidence, and the impact of crossing construction settlement is the lowest. Although the burial depth of underground pipelines has a minor effect on the settlement deformation, it has a significant impact on the stress of underground pipelines. The greater the pipeline burial depth, the higher the maximum Mises stress. Pipe diameter shows a relatively minor influence on both deformation and stress..Under the condition of crossing construction settlement, when the ground settlement is greater than 50 mm, the increase of differential settlement of underground pipelines is obviously slowed down. Although the underground pipelines of DN400 and DN600 show resistance to soil settlement, their maximum Mises stress still shows a significant growth trend. Among the three types of pipeline materials, the maximum Mises stress of steel pipes, ductile iron pipes, and gray cast iron pipes gradually decreases, but the safety factor and corresponding ground settlement threshold of steel and ductile iron pipes are much higher than those of gray cast iron pipes under identical pipe diameter and burial depth.The results can provide theoretical basis and engineering reference for the design optimization, settlement disaster prevention and control, and safe operation guarantee of underground pipelines.