In order to study and analyze vegetation coverage in Donghai County, Lianyungang City, China, GF-6 satellite data was used as the original data source, based on the traditional research of normalized vegetation index (NDVI) and pixel dichotomous model analysis methods, and further obtains the corresponding pure soil pixel (Ssoil) values and pure vegetation pixel (Sveg) values in the pixel dichotomous model data by different confidence methods, so as to estimate and analyze vegetation coverage by remote sensing.The results show that: (1) the estimation result of vegetation coverage is very sensitive to the value of confidence. When selecting the confidence, the reasonable selection of satellite characteristics, image characteristics and regional characteristics of the data source should be controlled between 2% and 10%; (2) Gaofen 6 satellite image can measure the vegetation coverage. The vegetation coverage level of Donghai County is mainly high and low in spatial state, which also provides value reference for the subsequent Gaofen 6 satellite in forestry application.