Aiming at the problems of complex process mechanism, excessive disturbance and difficult measurement of the weight control system of the rubber compound extrusion line in the tire industry, a control method combining Smith prediction and linear active disturbance rejection control (Smith-LADRC) is designed to realize the Stable control of tread weight. The simulation model established to compare the control effect with PID, LADRC and Smith-PID to verify its advantages. At the same time, the chaotic particle swarm algorithm (CPSO) introduced to adjust the parameters for the difficulty of parameter adjustment of this controller. The experimental results show that compared with the above three control methods, Smith-LADRC can make the system have better anti-interference and robustness. The control purpose is well achieved, and the rapidity of the system output response is improved. Compared with manual adjustment, the system output can be better controlled, while the parameter adjustment time is saved and the control efficiency is improved.