In order to study the control effect of bottom exhaust, ventilation and ceiling screen on the leakage of high-sulfur natural gas in closed narrow-long space, ANSYS Fluent 19.2 software was used to simulate the distribution characteristics of hydrogen sulfide and methane in high sulfur natural gas with hydrogen sulfide mole content of 5 % after 60s continuous leakage under various working conditions. The influence of bottom exhaust velocity, ventilation velocity and the sagging height of ceiling screen on the distribution of high-sulfur gas leakage were analyzed. The conclusions show that: The addition of ceiling screen will lead to the formation of vortex cluster of high-sulfur gas leakage. The sagging height of ceiling screen shall be set to 0.5 m. When the floor exhaust velocity is 4.00 m.s_-1^{, 0.63} m.s^_-1 ventilation can limit the leakage of high-sulfur natural gas to the ceiling screen section where the leakage port is located, which is the optimal combination of prevention and control. The ventilation system and bottom exhaust system can form air film on the surface of high-sulfur gas vortex, which can prevent the large-scale diffusion of high-sulfur gas.