To strengthen the heat transfer performance of the microchannel aluminum heat pipe array, the V-shaped groove was applied to the it, and the heat transfer characteristics of the heat pipe were studied using R1336mzz(Z), HFC4310mee and acetone at different inclination angles. The results show that when R1336mzz(Z) is used as the working fluid, the best filling ratio of the heat pipe is 23.2%. In the range of 45°~90°, the heat pipe has a lower temperature under the same heating power. The temperature of the evaporating is not affected by the inclination; At θ=90° and 0°, different working fluids make the heat pipe exhibit different heat transfer characteristics. At θ=90°, the heat pipe filled with R1336mzz(Z) and acetone has better thermal performance, and the highest equivalent thermal conductivity is 34.68 kW?m-1?K-1 and 35.67 kW?m-1?K-1, respectively. At θ=0°, the thermal performance of the heat pipes under the three working fluids has declined, but the good performance is still maintained. The heat pipe is filled with acetone and the heating power is between 0 and 160 W. The equivalent heat transfer coefficient in the horizontal position can reach more than 72.5% of the vertical position, and the V-groove microchannel aluminum heat pipe array has the highest equivalent thermal conductivity of 22.28 kW?m-1?K-1; The channel can provide a strong capillary driving force, and can alleviate the adverse effect of the heat pipe due to the weakening of gravity, which is an important reason for the better heat transfer performance of this kind of heat pipe.