Due to the difficulty of obtaining data from few radiation sites and the low applicability of existing surface radiation estimation models in Yunnan Province, a high-precision solar radiation estimation model suitable for Yunnan Province needs to be explored. A Multi-factor Comprehensive Estimation Model (MFCE) applicable to Yunnan Province was constructed by using meteorological and remote sensing data to screen out 7 factors such as altitude and sunshine percentage, and the accuracy of parameters and calculation results in the model were calculated month by month. The correlation coefficients of the MFCE model were above 0.7 for each month, which increased 0.3 on average compared with other models; the root mean square error distribution was between 16.21 and 33.73 MJ-m-2, which decreased compared with other models. The estimation results and accuracy of the MFCE model are greatly improved compared with the traditional models, and the proposed model provides help and scientific basis for the study of solar radiation in Yunnan Province and the rational use of solar energy.