Research on the optimization methods of Surface integrity control technology region of grinding superalloy GH4169DA. Through the orthogonal experiment of cylindrical grinding, the experience formula of surface integrity characteristic of the grinding process parameter sensitivity and relative sensitivity are built,the process parameter stability region and instability region are acquired. Using the extreme difference analysis method facing the orthogonal experiment, the influencing curves of process parameters on surface integrity characteristic are obtained, Surface integrity control technology region is achieved. Results show that the surface roughness and the surface residual stress are most sensitive to the variety of the workpiece speed, the surface microhardness is most sensitive to the variety of the wheel speed in cylindrical grinding. The grinding process parameter optimizing interval of guarantee a stable surface integrity is acquired: the workpiece speed vw 12～22m/min, the radial feed ap 0.005～0.01mm, the wheel speed vs 20～25m/s, in this optimizing interval, the surface roughness and the surface microhardness are stability, and the surface residual compressive stress is great. The theoretical method and the test datum can be used for the surface integrity control of superalloy.