Aiming at the problem that the deformation of large cross-section transportation roadway is serious and difficult to control, the mining roadway in the middle section 520 of a mine is taken as the engineering background. The field investigation of roadway deformation and failure pattern and the acoustic wave test of loose circle are carried out, and indoor rock physical and mechanical parameters test and theoretical calculation analysis. The results show that the surrounding rock stability of roadway in this mine is poor and the lithology is complex. the geological environment of the mine is medium, and the loose circle is 1.4 ~ 1.6 m, which belongs to IVa type rock of large loose circle. Based on the above research, two different forms of surrounding rock control measures of “ shotcrete-anchor support ” and “ advance support ” are proposed for roadway crossing different geological environments, and the support parameters are preliminarily determined. Finally, FLAC3D numerical simulation software is used to optimize the support parameters and verify their rationality, that is, shotcrete-anchor support ( bolt length 1.8 m ) and advanced support ( steel arch spacing 0.6 m ) can better control the deformation and stability of roadway surrounding rock. The research results provide a theoretical basis for the roadway support design in the mining area, and also provide reference ideas for the design and construction of similar projects.