In view of the mechanical characteristics of prestressed high-strength concrete (PHC) pipe piles under seismic action, considering the effect of corrosion of welded joint, the three-dimensional model of pipe pile-soil was established by using finite element software ABAQUS. The seismic load was simulated by applying horizontal low cyclic loading on the top of the pipe pile by using the pseudo-static method. The influence of vertical load and corrosion degree of the welded joint on the seismic performance of PHC pipe piles was studied, and the improvement measure of adding non-prestressed rebars was put forward. The results show that the existence of vertical load can reduce the energy-dissipation capacity of pipe piles and improve the horizontal ultimate bearing capacity of pipe piles. The stress of the weld seam at the welded joint is the largest, and it is the first to yield after the corrosion of welded joint. The horizontal ultimate bearing capacity of the pipe pile decreases with the increase of corrosion degree of welded joint, which can not be ignored. By equipping a certain number of non-prestressed rebars in the pile body, the stress of the weld seam at the welded joint can be reduced, and the energy-dissipation capacity of the pipe pile can be effectively improved, and the horizontal ultimate bearing capacity of the pipe pile can be increased, so as to reduce the adverse effect of corrosion of welded joint on the seismic performance of the pipe pile.