In view of the deformation and failure characteristics of mixed ground under different lateral pressure coefficients (0.5~2.0) excavated at large burial depth in the central western China compressional orogenic belt, the finite difference program FLAC3D was used to simulate the deformation and failure of three different construction types of mixed ground. At the same time, combined with the analysis and comparison of the analytical solutions of homogeneous soft rock and hard rock, it is found that the displacement of mixed ground during excavation is smaller than that of homogeneous soft rock, and the displacement of the former changes to the side wall with the increase of lateral pressure coefficient. The main stress in hard rock is higher than that in soft rock. The largest plastic radius of soft rock is the type of former soft and later hard type, which is much larger than that of the upper and lower superimposed types of mixed ground. The latter is close to the plastic circle radius of homogeneous soft rock at this depth. The result could be used for tunneling design and safety construction.