It is well known that the traditional silicon MEMS piezoresistive pressure sensors generally have temperature drift and time drift errors. In view of it, an anti-interference system for MEMS pressure sensors is designed by using the method of constant temperature control and constant current source correction. Firstly, the parameters of the sensor and the principles of temperature drift and time drift are briefly introduced. Secondly, an anti-interference circuit system related to sensor is designed and made. Finally, the system is tested experimentally. The results show that the temperature drift and time drift errors of the sensor could be reduced in the anti- interference system. The absolute value of thermal zero drift decreases from 0.0652%FS/℃ to 0.00788%FS/℃ after constant temperature, and the absolute value of thermal sensitivity drift decreases from 0.118%FS/℃ to 0.0153%FS/℃. As the same, the prediction error decreases from -3.436~0.875 kPa to -2.086~1.765 kPa after time drift compensation. The design of anti-interference system has a certain reference value for temperature drift, time drift compensation of MEMS pressure sensor.