Oxidation fluid is the core of the formation of sandstone type uranium deposit, and the heterogeneity of sand body is a key factor to control the distribution of oxidation zone and uranium orebodies. Therefore, it is important for uranium exploration to determine the sand body parameters that restrict the development of oxidation zone. Taking the upper member of Xishanyao Formation in Honghaigou deposit as the object, the key factors affecting the spatial distribution of oxidation zone and uranium ore body will be extract from the statistical analysis of a large number of drilling data by cluster analysis and correlation analysis, and then to explore the influencing mechanism. The results show that the two parameters of sand body thickness and sand body ratio have the best correlation with the large-scale development of oxidation fluid in the main channel sand body. The sand bodies of uranium mineralized boreholes are related to two kinds of parameters: high sand content, large number and thickness of interlayer. The thick sand body with high homogeneity controls the development of oxidation zone, and the heterogeneous sand body around its edge directly locates the occurrence of uranium ore body. The research results of this paper have important guiding significance for exploration of oxidation zone and ore body location prediction of sandstone type uranium deposit.