T0 study the effect of Mongolian medicine Gurigumu and its compound Gurigumu-13 on concanavilin A (Con A) induced autoimmune hepatitis in mice and its influence on INF-γ/STAT1/VCAM-1 pathway. The BALB/c mice were randomly divided into control group, model group, positive group, Mongolian medicine Gurigumu low, middle, high dose groups and Mongolian medicine Gurigumu compound low, middle, high dose groups. After continuous intragastric administration for 1 week, 1 hour after the last administration, Con A was used to establish acute liver injury. ELISA was used to detect the contents of TNF-α and IFN-γ, the degree of hepatic cells apoptosis was detected by TUNEL and Flow. Western blot was applied to detect the expression of STAT1, p-STAT1 and VCAM-1. The results show that Mongolian medicine Gurigumu and its compound Gurigumu-13 can effectively reduces the contents of TNF-α and IFN-γ in the blood serum (P<0.05); inhibits the liver cell apoptosis induced by Con A (P<0.05); decreases the protein expression of STAT1, p-STAT1 and VCAM1 (P<0.05). It is concluded that Mongolian medicine Gurigumu and its compound Gurigumu-13 has the function of protectiving Con A-induced acute autoimmune hepatitis, and its mechanism may be related to INF-γ/STAT1/VCAM-1 signaling pathway.