Aiming at the problems in shale gas fracturing flowback fluid treatment process, such as conventional reverse osmosis membrane desalination is difficult to meet the demand of high Total Dissolved Solids (TDS), crystallization evaporation heat exchanger scaling and oxidation treatment cannot achieve desalination effect and so on, and combining the urgent need for treatment of shale gas fracturing flowback fluid, the water quality of shale gas fracturing flowback fluid in South Sichuan was analyzed and a shale gas fracturing flowback fluid treatment technology based on multi-stage reverse osmosis desalination was formed by using combination of water softening, flocculation-sedimentation, and multi-stage filtration as pretreatment process and using high and low pressure reverse osmosis membrane in series as advanced treatment process. After the pretreatment, the hardness and TSS of the flowback fluid can be reduced to be 120 mg/L and 7-20 mg/L, respectively; Furthermore, after the advanced treatment by connection of SRO membrane and RO membrane, the desalination treatment of the flowback fluid with TDS of 6 × 104 mg/L can be realized by taking advantage of a large number of bumps set on the guide plate, which make the filtrate to form turbulence and to avoid membrane blockage. The field test of this technology was carried out in Changning shale gas block. The results showed that when the flowback fluid with TDS of 2 × 104 - 6 × 104 mg/L was treated by this technology, the yield of clean water reached 56.5% - 81.36%, and the TSS, chloride content, COD, ammonia nitrogen and other indexes of clean water all met the first-class index requirements of GB8978-1996 and DB51 / 190-93, realizing the reduction of shale gas fracturing flowback fluid.