Abstract:Study the medication rules of TCM(traditional Chinese medicine) prescriptions for the treatment of primary hepatic carcinoma based on data mining and network pharmacology to provide a reference for the TCM prescriptions compatibility against primary hepatic carcinoma in clinical diagnosis and treatment. 211 effective TCM prescriptions against primary hepatic carcinoma were collected and screened from clinical and related literatures,and the traditional Chinese medicine assistant platform was used to perform data mining analysis on the key drug combinations in the obtained prescriptions.Select the targets of active ingredients of key drug combinations from TCMSP and other databases.Search for targets related to primary hepatic carcinoma in disease databases such as MalaCards,CTD,TTD.Select their common targets,which are the general targets of key drug combinations against primary hepatic carcinoma.GO/KEGG pathways enrichment analysis of general targets can be obtained by using DAVID platform.Key targets can be obtained by topology analyzing with Cytoscape 3.6.1 software and can be verified by molecular docking by CB-Dock Web Site.The reliability of the results of this study is verified by comparing with the experimental results of related literatures. Through data mining and network pharmacology,23 groups commonly used drugs (support≥50),24 groups strongly related drugs (confidence≥0.95)and 36 groups clustering drug combinations were obtained;124 general targets and 16 key targets against of primary hepatic carcinoma were obtained;450 biological processes,37 cellular components,48 molecular functions and 44 KEGG signaling pathways were obtained (P≤0.01),and the p53 signal pathway have been verified by the experimental results in the relevant literatures;It was also found that Poria,Atractylodis Macrocephalae Rhizoma,Codonopsis Radix,Scutellariae Barbatae Herba and other drugs appeared more frequently in prescriptions for the treatment of primary hepatic carcinoma. In the clinical treatment of primary hepatic carcinoma,traditional Chinese medicine usually focuses on tonifying deficiency and clearing away heat,giving attention to promoting blood circulation and regulating qi.It mainly treats the meridians and collaterals of liver,spleen,lung and kidney,paying attention to the combination of clearing and tonifying,and giving attention to both deficiency and reality;Key drug combinations mainly treat primary hepatic carcinoma by inducing cell apoptosis,blocking the cell cycle,anti-angiogenesis and regulating inflammation.