One of the major challenges in molecular biology is to understand the precise mechanism by which gene expression is regulated. Reconstruction of regulatory networks is essential to modeling this mechanism. Most research work in constructing gene networks either assumes that there is no time delay in gene expression or that there is a constant time delay. An extended approach for modeling a gene networks with Multi-Time Delay by using a DBNs model is provided. It is more accurate in determining the gene structure as compared to the traditional methods. It is evaluated using time series expression data measured during yeast cell cycle. The results suggest that it is possible to unambiguously determine gene regulatory network with time delays from time series gene expression datasets.
崔光照 张勋才 曹祥红 董亚非 王延峰. 基于动态贝叶斯网络的多时延基因调控网络构建[J]. 科学技术与工程, 2005, (17): 1247-12511259.
Cui GuangZhao;Zhang XunCai;Cao XiangGong;Dong YaFei;Wang YanFeng. Reconstruction of Gene Regulatory Networks with Multi-time Delay Based on Dynamic Bayesian Networks[J]. Science Technology and Engineering,2005,(17):1247-12511259.