Sherlock is a domain analysis methodology for the extraction of reusable frameworks. Sherlock is based both on Proteus and on FODA domain analysis techniques. The input of Sherlock is a description of the domain based on domain applications, literature, user requirements, and interviews with domain and market experts. The output of Sherlock is a framework comprising a set of components organized in architectures. Domain analysis are the main features of Sherlock and present a case study regarding the development of a graphic user interface framework for business and management information systems.