In order to improve the safety management level of airlines, a method based on DEMATEL and Choquet integral coupling is proposed to evaluate the flight operation risk of airlines. Firstly, on the basis of identifying the flight operation risk factors of airline, the DEMATEL method is used to calculate the comprehensive impact matrix of factors. The comprehensive influence matrix is used to calculate the degree of influence, the degree of influence, the degree of centrality and the degree of cause of the factors, and to determine the causal attributes of the factors and the key factors. On the basis of calculating the key risk factors by DEMATEL method, the risk evaluation model is built by Choquet integral to evaluate the flight operation risk of airlines comprehensively. The results show that the risk assessment model can eliminate the correlation between risk factors and achieve a reasonable and effective evaluation of airline flight operation risk.