As a kind of thermal oil recovery technology using burning heavy components to heat formation to achieve oil displacement, in-situ combustion reservoir has attracted more and more attention because of its high thermal efficiency and obvious oil displacement effect. But the successful application of fire drive is not widespread at present, mainly due to the lack of understanding of the oxidation rate in different oxidation stages of fire drive, and it’s difficult to form a reasonable design scheme of gas injection rate. In this paper, the static reactor experiment is used to measure the pressure change with time in the low temperature stage, and the low temperature oxidation reaction rate is calculated by the pressure drop method. At the same time, the oxygen content changes before and after high temperature reaction are measured by the combustion tube experiment. The high temperature oxidation reaction rate is obtained according to the gas state equation, and according to the reaction rate of different stages, combined with the actual situation of fire drive, reasonable gas injection rate is given to provide reference and guidance for subsequent fire drive scheme design.