In order to research the geological process and the magmatic evolution during Precambrian in the middle of Inner Mongolia, we studied the zircon U-Pb ages, whole-rock major and trace elements and Sr-Nd-Pb-Hf isotope of the Neoproterozoic granites from Zhaojinggou in the northern margin of North China plate. On the basis of geological survey and petrographic observation, the results show that the Neoproterozoic granite have high contents of SiO₂(72.54%～75.67%), alkali(8.70%～10.15%), and relatively high Ga/Al ratios. Additionally, the content of Ca, Fe and Mg is low, and the results display enrichment in Rb, Th, U, Ta, Hf and depletion in Ba, Sr, P, Ti. It is characterized by a gull-wing shaped REE patterns with negative Eu anomalies. These data indicate the affinities with post-orogenic A-type granite. Zircons from the granite have typical oscillatory zone structure, which exhibits the magmatic genesis. LA-ICP-MS zircon U-Pb data from the sample yield Neoproterozoic crystallization age of 765±5.0Ma, which reflects the intrusion time. ε_Nd(t) values of these samples ranges from -7.3 to -2.7 and ε_Hf(t) values ranges from -15.9 to -6.3.The two-phase model age of the crustal(t_DM2) ranges from 2045 to 2662 Ma. These data shows that the source materials of the granites were most likely originated from the old crust with a little mantle-derived materials, which may be caused by the upwelling of the mantle magma in the extensional tectonic setting. The formation of the Neoproterozoic A-type granites in Zhao Jinggou is related to the partial melting of Palaeoproterozoic ancient crustal materials in the northern margin of the North China plate. It is regarded as the responses to the break-up of Rodinia supercontinent.