In order to solve the problem of high pressure deficiencies in the development of the 33rd oil reservoir in Wen 33. Low concentration (0.05% effective concentration) antihypertensive agent XH207B is preferred indoors, and the core morphology modification experiment is carried out to invert the wettability of the hydrophilic rock in the near-well zone, and the hypotensive agent XH207B is injected into the core to observe the change characteristics of core micro-morphology before and after wetting alteration, reveal the working principle of anti-hypotonic injection, and observe the seepage law of relative permeability change of oil-water two-phase in hydrophilic reservoir by oil-water two-phase core flooding experiment. The law provides guiding significance for on-site construction and achieves the purpose of reducing blood pressure. The results of laboratory experiments show that at a lower concentration of 0.05%, the XH207B solution can make the hydrophilic rock reach the intermediate wetting state (contact angle is close to 90°), and it is mainly attached to the pore throat in the pore throat of the rock. The wall prevents the expansion and migration of clay minerals in the hydrophilic rock and changes the oil-water interface characteristics in the near-well zone. At the same time, the anti-hypotonic injection agent solution is wrapped in the oil phase in the form of “micro-water beads” to promote the emulsification of oil-water and improve the hydrophilicity. The relative permeability of the two phases of the reservoir oil and water finally caused the injection pressure difference to decrease to a certain extent, and the range of decline was 1.22%~6.18%, which achieved the effect of reducing blood pressure.