In order to solve the balling problem of PDC bit in rapid drilling in Zhujiang formation in Pan Yu. Based on the PDC bit model, the nozzle angle combination is further optimized by numerical simulation method. The bottom hole flow field characteristics of the main nozzle and auxiliary nozzle are analyzed by using the standard two-equation model under different injection inclination combination. The results show that the model used in this study the inclination of No 1 and 3 nozzles is 20° and 15° respectively, which can optimize the distribution of downhole flow field. The change of injection inclination angle of No 1 4 and 5, which is far away from the main blade has a great influence on the bottom hole flow field. In addition, the No 1 nozzle inclination within limits, which has a limited impact on the bottom hole flow field. It is applied in the design of personalized 215.9mm five-blade PDC bit. The high footage and ROP are obtained, the problem of bit balling is solved in drilling.