According to the characteristics of the service environment of vehicle equipment, the sealing performance of the door of a certain type of vehicle under the action of deep water pressure is studied. Firstly, the finite element modeling is established according to the geometric characteristics of the door. For the sealing strip model, an efficient segmentation modeling method is adopted for the convergence of the solution, and then the finite element nonlinear analysis is carried out by HAJIF software to obtain the Deformation and stress values of the door and rubber weather strip. The research results show that: in the place where the water pressure is small at the top of the door, the sealing performance of the rubber is less affected by the water pressure, and in the bottom of the door, where the water pressure is large, the contact state changes obviously, which has a great influence on the sealing property. The research results can be used as a reference for the design of sealing strip products, and provide some help for subsequent research and development personnel to develop the door sealing system.