In order to prevent the high-pressure discharge pipe of the fracturing pump from vibrating in the working state, it is found through finite element simulation that the natural frequency of the high-pressure manifold is close to the working frequency of the fracturing pump, and there is a danger of resonance. Therefore, according to the vibration mode obtained by simulation, the constraint mode is improved, and the improved result is obtained by finite element simulation analysis. The analysis shows that the high-frequency manifold after the improved constraint mode has a natural frequency much larger than the working frequency of the fracturing pump, effectively avoiding the working frequency range of the fracturing pump is opened. Finally, the finite element simulation calculation results are verified by the experimental modal analysis of high-pressure manifolds, which provides a basis for anti-vibration and application of high-pressure manifolds.