High-strength cement base material was usually show a lot of problems such as easy cracking and shrinkage properties. Therefore, high-strength cement base material was prepared by nano-MgO to analysis the modified effect of nano-MgO on mechanical properties and shrinkage properties of high strength cement base material.The results showed that: when the dosage of nano-MgO is bigger, the initial setting time and final setting time of high-strength cement base material is the shorter. The shorten quantity of final setting time is relatively large and liquidity reduced. 0.5%~4.0% nano-MgO can improve the compressive strength and flexural strength of high-strength cement base material, and the flexural strength is about 1/5~1/7 of the compressive strength. The flexural strength and compressive strength reached the maximum when the dosage is 1.0%. Drying shrinkage and mass loss of high-strength cement base material increased with the increase of dosage of nano-MgO continuously decreased, and there is a linear relationship between both. In conclusion, it found that nano-MgO can be modified high strength cement base material of workability, mechanical properties and shrinkage properties.