In order to understand the driver's influence on the myoelectric characteristic index MPF when driving on the plateau low-oxygen section, the longitudinal profile of the road, recording the myoelectric signal of the driver on the plateau road using a biofeedback detector, Combining the longitudinal profile of the road G314 route, analyzing the change law of MPF in the driving of the plateau highway. Quantitative analysis of the relationship between MPF and altitude H, vertical curve radius r, and slope ω. Research shows: Altitude is the main factor affecting the change of driver's MPF value when driving on highland highways; It is negatively correlated with the slope difference; There is a collinear relationship between altitude and vertical curve radius. With the increase of altitude and the decrease of vertical curve radius, MPF value decreases rapidly.