The time-varying of load and stochastic variability of distribution generation (DG) deteriorate the voltage control based on real-time reactive power optimization. Voltage and reactive power control strategy for distribution network with the presence of multiple DGs is presented in this paper to address the above issue. The nodes’ reactive power injections was deduced based on the voltage deviation of real-time detection and the sensitivity matrix of reactive power to voltage deviation, so that the shunt capacitor bank set number can be determined. Optimum transformer tap position is estimated by improved recursive Bayesian approach. The optimum step voltage regulator position is calculated based on the Remote Terminal Unit (RTU) data which are collected from the selected points of distribution feeders. And next moment the control center adjusts the control variables according to a target value which guarantees the real-time character. Simulations are carried on the 33-bus IEEE test system to illustrate that the approach is reliable and with high efficiency, it is also well fit for on-line application.