Vulnerable to heterogeneous on DRA multichannel digital audio signal interference, lead to the useless information in the audio signal, the audio quality decline.Put forward A new heterogeneous signal interference on DRA multichannel digital audio signal under weighted fusion method, designed A collection system acquisition on DRA multichannel digital audio signals at the same time, will get the signal in the DSP weighted fusion processing, the use of A/D conversion chip for conversion.Introduced on DRA multichannel digital audio signal weighted fusion principle, before the acquisition signal transmission to the fusion center for quantitative processing, combined with the quantitative statistical properties of the process of the weighting coefficient is derived, based on the weighted coefficient of design integration function, make the fusion function and useful on DRA multichannel digital audio signal in statistical sense, to a great extent so as to realize the weighted fusion of audio signal.The experimental results show that the proposed method can achieve effective on DRA weighted fusion of multichannel digital audio signal under different signal-to-noise ratio can keep lower root mean square error, high precision weighted fusion.