Abstract:objective: to study the different frequency of aerobic exercise on the influence of Resistin secretion in diabetic patients;Methods: the experiment will be from August 2015 to September 2015 in a hospital were as the research object, the 60 cases of diabetes patients randomLy divided into control group, its low frequency aerobic exercise group and medium frequency aerobic exercise group, control group patients with routine nursing only, blood sugar monitoring and hypoglycemic therapy, low frequency aerobic exercise group of patients in the control group on the basis of walking, walking, for medium frequency aerobic exercise group of patients in the control group on the basis of fast walking and jogging.Results: after the experiment of low frequency glycosylated hemoglobin aerobic exercise group was significantly lower than control group (P<0.05) and medium frequency aerobic exercise group of glycosylated hemoglobin is lower than the control group, with very significant difference (P<0.01);After the experiment of medium frequency aerobic exercise group is lower than the control group, fasting glucose has very significant difference (P<0.01).After the experiment of low frequency contents of TC, TG, LDL aerobic exercise was significantly lower than control group (P<0.05);Experiment after moderate intensity aerobic exercise group TC, TG, LDL levels significantly lower than the control group, with very significant difference (P<0.01), HDL levels significantly higher than that of control group (P<0.05).After the experiment of low frequency aerobic exercise group insulin levels significantly higher than that of control group (P<0.05);After experiment and insulin levels of medium intensity aerobic exercise group was obviously higher than that of control group, with very significant difference (P<0.01), Resistin levels significantly lower than that of control group (P<0.05).Conclusion: aerobic exercise can reduce the content of serum Resistin, is helpful for the recovery of diabetes patients.