In order to accurately determine the spatial position of the interlayer oxidation zone sandstone type uranium deposits, the abnormal formation mechanism of metal active state was discussed based on the metallogenic characteristics,that indicator elements in weak oxidation zone is shown as high anomaly, reduction zone as low anomaly, uranium deposit usually located in the transition between high anomaly and low anomaly. Taking heshituoluogai basin as example, the characteristics of sedimentary facies and uranium source was analyzed, think the Tiechanggou granite in the west side of the study area has good uranium source conditions, uranium transport from south west to north east, and metallogenic prospect area was divided based on anomaly pattern of metal active state.