[Abstract] Background: Most of the pain is in the labor of many patients, but it has serious side effects. Therefore, it is urgent to find a safe and effective drug for treatment of neuropathic pain. Huangqi Guizhi Decoction of five ingredients as traditional drugs have a certain therapeutic effect. Astragaloside as the main component of Huangqi Guizhi Decoction of five ingredients. Methods: SD rats were used to repair the nerve injury caused by CCI model. The progress of cell damage repair was studied by using the methods of Western blot and immunohistochemistry. Results: AG could significantly down regulate the expression of P2X3, TRPA1 and TRPV1 in DRGs, which played an important role in the process of pain delivery.