Gas hydrates play a significant role in the flow assurance of oil and gas pipelines, posing one of the most serious problems. Hydrate kinetic inhibitor as an alternative method to control gas hydrate plugging has drawn much attention for oil/gas production and transportation department. This paper first investigated several three methods of the development and assessment of hydrate kinetic inhibitor, including temperature-pressure measurement apparatus, visual observation method and simulated hydrate flow loop. Next, several new technologies developed in recent years were introduced, such as differential scanning calorimetry, laser measurement technology, micromechanical force apparatus and molecular simulation. Finally, the advantages and disadvantages of each method were summarized and analyzed, and the proper suggestion was also proposed.