Abstract:The light field camera captures the position and direction information of the light, but it sacrifices a certain direction resolution and reduces the image clarity. Presently, Lytro camera as a consumed light field is small, portable and easy to shot, but its’ image resolution is very low. In order to solve this problem, proposes a method of image sequence all-focus based on the micro lens array. First processed the original image by image coding, calibration and color correction, then constructed the model of image sequence, take out the different image sequence from the processed image information, On the principle of spatial domain integral refocus, determined the sub images’ best focal point by image sharpness evaluation operator, used image fusion method to complete the image all-focus. The experimental results show that using this method could improve the spatial resolution of the image, and get more clear all-focus image.