Electro-osmosis is an important method of processing soft clays. Theory of electro-osmosis consolidation assumed clays were saturated, but most of the clays processed in practical engineering were unsaturated, the reinforcement of unsaturated clays by electro-osmosis still needs to be studied. The electro-osmosis contrast tests of clays in different saturation states were conducted by using the self-made electro-osmosis instrument, and the reinforcement effect of unsaturated clays was studied by comparing the changes of current, displacement, settlement, moisture content and ultimate strength. Considering the increasing range of strength, the range weakened as the decrease of the moisture content. The results showed that comparing to the saturated clays, the reinforcement of unsaturated clays by electro-osmosis is effective, but is inferior to that of saturated clays.