It is difficult to detect the radial flow during pressure built-up period for the low permeability reservoirs. This brings much problem for well test interpretation. In this study, take the typical low permeability reservoirs for example, using the well test data in different periods of different space well test, combing with the reservoir geological data and the production history, and a new well testing analysis method is proposed. The method can determine the reasonable well test interpretation model, and get the reliable results. It can provide the technical reference for the low permeability reservoir well test interpretation.