Comprehensive intervention study swimming in obese adolescents cerebral metabolism improve sexual function, can prevent and treat obesity related diseases of the digestive system, improve dietary function in obese adolescents. Through determination of adolescent obesity patients with brain metabolism and vital capacity index, blood pressure index, adopt the method of fluorescence titration determination designed.the Gn - NA (n = 1 ~ 3) on the content of methanol/DMSO cerebral metabolic characteristics analysis, finally by K - center algorithm to construct comprehensive (Holo - directed) and half bearing (Hemi - directed) of obese patients carbonic anhydrase water chains, swimming is built up under the comprehensive intervention of obesity patients with brain metabolism to improve related factors of the model. The experimental results show that: through the analysis of swimming exercise comprehensive intervention effect on obese adolescents brain metabolism, accurately grasp the level of obese adolescents obesity in patients with cerebral metabolic changes, this paper model of adolescent obesity patients with cerebral metabolic distribution rate of convergence, by swimming exercise effective increase fat burning rate, to ensure the healthy body, the prevention of the diseases related to obesity syndrome in clinical practice has important guiding significance.