The coupling relationship between Tibetan Plateau uplifting and the lithologic reservoirs formation of southwestern Qaidam Basin has been detailedly analysed on the base of previous researches. It is summarized that Tibetan Plateau develops weakly at the early time and strongly at the last stage. The lithologic traps develop more early and multiperiod than structural traps in uplift period I. The three oil filling respectively occur in the B stage of uplift period I(E32), C stage (N21) and E(N23) stage of uplift period II. Combining with the discovery of boihng inclusion, it is concluded that the remote tectonic stress of Tibetan uplifting is the main accumulation dynamics in study area. The hydrocarbon in high-pressured source rocks can be expelled abruptly, migrating along the opened fractures and accumulating in the normal-pressured system. The strong tectonic activity of Tibetan Plateau uplifting II period is the main cause for the forming of litologic reservoirs in southwestern Qaidam Basin. So, it is clearly that fracture of conducting system is the main controlling factor for accumulation regulation of litologic reservoirs in this kind of plateau saline lacustrine basin, which is characteristiced as a self-reclusive system.