Holding water features of hipparion red clay make it easily lead to a series of engineering problems as roadbed filler. Through the four factors quadratic orthogonal rotation test design, the four main factors affect the shear strength which contain moisture rate,degree of compaction, particle size and rubber particle volume are selected as the test factors, cohesion C and internal friction angle as an indicator of triaxial test. The study found that the relationship between water content, degree of compaction, rubber particle content and C, can be characterized by multiple regression equation. The rubber particle size hasn’t significant influence on hipparion red clay’C and . When the range of moisture content is in 5% to 25%, degree of compaction is in 87% to 99%, the particle content is in the range of 5% to 25%, hipparion red clay’C and gradually increase along with the decrease of water content, compaction degree increase. But the higher dosage of rubber particles, the smaller C and the bigger . Degree of compaction and water rate, degree of compaction and rubber particles dosage have effect of interaction on hipparion red clay C and . In addition, the model of response surface win C or can reflect actual condition of test.