A series of hydrodewaxing catalysts with different amounts of Ni are prepared by extruded and incipient impregnation, using ZSM-5 zeolite and pseudoboehmite powder as raw materials, and nickel nitrate as the source of nickel. The catalysts are analyzed by the method of N2 adsorption and desorption, XRD and Py-IR. The catalytic dewaxing effect of these catalysts are evaluated on a fixed bed reactor using hydrocracking tail oil as the feed stock. The results show that the pore structure and acidity of catalyst could be improved by the addition of nickel. Under the condition of reaction temperature 280oC, reaction pressure 15MPa, LHSV 1.0h-1 and V(H2)/V(Oil) 500, a lube base oil, with freezing point of -19oC, yield of 62.4% and viscosity index of 92, can be obtained by using 5% Ni loading catalysts.