According to the characteristics of bad physical property and strong heterogeneity of low permeability sandstone reservoir in the Xifeng area, Ordos Basin, a set of targeted property modeling method was developed, starting from the formation mechanism of low permeability. Based on porosity modelling controlled by the “F-sand model”, the traditional “Sequential Indicator Simulation” concept was applied into the permeability modeling, by means of Bayes Indicator simulation combined with covariant parameters. The result shows that the effective modeling methods presicely characterized the zones of secondary pore and relatively high permeability, controlled by the separated sand content as well as types and intensity of diagenesis. The modeling result objectively reflected the severe heterogeneity of low permeability reservoir and improved the random modeling scheme. The accomplishment and output of this research can provide reasonable geological model for reservoir numerical simulation and development planning in a field with this type of reservoirs.