When particle discrete element method is carried out to study the mesoscopic mechanics properties of rock and soil, how to determine the relationship between the macro mesoscopic parameters must be a problems, however, the selection of mesoscopic parameters has certain artificial and uncertainty. In this paper on the basis of a large number of numerical triaxial compression test, rock and soil granule material is established three-dimensional mesoscopic parameters (particle contact friction coefficient stiffness than particle bonding strength of adhesive strength than the particles) and macroscopic mechanical strength parameters (c, φ) the relationship of calibration. The results show that the mesoscopic parameters of particle contact stiffness ratio and particle friction coefficient of the shear strength parameters of rock and soil particle materials (c, φ), the other parameters particles ignore its influence; Using multivariate nonlinear fitting method, presented quantitative related mesoscopic parameters and macroscopic shear strength parameters (c, φ) calculation formula and through a mechanical state of the slope in a creep state parameters corresponding relation are verified, the predicted formula can provide parameters for related mechanical calculation and simulation quickly determine the basis.