This paper studies the role of permeability on the seismic response of sandstone reservoirs characterized by patchy gas-water saturation. Starting from white’s seminal model ，Based on Johnson model, analyses the seismic attenuation and velocity dispersion characteristics and analyses the role of permeability on them in the different gas saturations. The results show: Within the scope of the seismic wave frequency band, seismic wave produces obvious attenuation and velocity dispersion when seismic wave goes through the gas reservoir and the sensitivity of attenuation and velocity dispersion to permeability is very strong. Numerical simulation of permeability effects on the reflection seismic date with different incidence angles. Numerical simulation of permeability effects on seismic attenuation and velocity dispersion for normal-incidence seismic data. For soft and highly porous sand reservoirs, the normal-incidence seismic reflection data are very sensitive to permeability. Under certain conditions, the seismic reflection data that the surface has received are very sensitive to permeability of gas reservoir.