Erosion in fracturing play an important role in the failures of oil tubing for high slurry fracturing fluid flow. In our study, the effects of erosion time, slurry velocity and sand content on the weight loss rate of P110 steel for Erosion-corrosion with 3.5wt% NaCl containing sand were investigated in the self-made jet experiment device. Results show that the weight loss rate begins to reach a plateau after 60 minutes. In addition, the power law model is appropriate to describing the weight loss rate with the slurry velocity. Comparing with the conventional power law equation Ev=KV_n, the revision equation adding a corrosion factor M meet the experiments results, especially in the low slurry velocity in which the corrosion dominates the total weight loss. The total weight loss is maximum when the sand containing is 25 kg/m₃,then it decreases firstly and increase slowly with the sand containing due to the particles collisions become intense. The results of this study can provide some advices to the application in the new fracturing process of P110 oil tube.