This study is aimed to explore the possibility of improving cognitive dysfunction after epilepsy by combined administer of polyene phosphatidyl choline (PPC) and sodium valproate (VPA). Rat epilepsy was induced by lithium-pilocarpine. After administration of VPA and PPC for four weeks, the behavior and cognition of epileptic rats were investigated by Morris water maze test. Hippocampal neurons of epileptic brains was counted after Nissl staining. Compared that in the normal control group, number of seizures was reduced and 1earning and memory latency of the drugs group was prolonged significantly. Positive Nissl staining cells in hippocampus from drugs group is more than other groups with a statistically significant. Administer of PPC and VPA combined is beneficial to reverse cognitive impairment of epileptic rats.