Objective The characterization of behavioral and image of completely unilaterally 6-hydoxydopamine-lesioned Parkinson rat model were investigated. Methods we gave two 6-hydoxydopamine injection into right medial forebrain bundle (MFB) to setup completely unilaterally Parkinson rat model and observered their abnormal behavioral under both nature and apomorphine used situation. we used the 11C-?-CFT and 18FDG Micro-PET to image change of the ability of the region of the rat brain . Results compared with the inactive side, the initiation of stepping movements by the left(contra-lateral)paw are greatly reduced, the initial time was prolonged and the rate of using left paw reduced when the rat in the nature situation; under the apomorphine inducing, the rats show the contraversive rotation and abnormal involuntary movement, such as limb dyskinesia ,axial dystonia and masticatory dyskinesia. The 11C-?-CFT image showed the depletion of presynaptic maker DAT in the lesion side of the striatum and the FDG image showed the reduced ability in the lesion side. Conclusion completely unilaterally Parkinson rat model showed extensive neuropathology and profound loss of sensorimotor, analogous to severely rigid-akinetic terminal stage of human disease.