Abstract:Biodegradable thermosensitive gels are a class of novel drug delivery carriers that are flowable liquid at room temperature but become solid gels at body temperature. In this thesis, a type of biodegradable thermogelling copolymers containing novel component or structural unit PDO were synthesized by solution polymerization with two-step olymerization. A combined techniques and experiments including 1H-NMR, degradation tests were employed to characterize the copolymers, investigate sol-gel transitions of the copolymer solutions and to investigate degradation and drug delivery properties of the gels. In conclusion, we have acquired a type of thermosensitive gels with suitable sol-to-gel transition temperatures that could be adsorbed in human body in aropriate time and will not produce a lot of acidic by-products during the degradation time. These thermosensitive gels are injectable with promising aplications as long-term drug delivery carriers, especially for acidic sensitive macromolecular drugs and hydrophobic drugs.