温敏型聚对二氧六环酮水凝胶的制备
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台州学院青年基金(2010QN16)


Synthesis of biodegradable thermo-sensitive gels of p-dioxanone
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    摘要:

    可生物降解温敏型水凝胶是一类在室温或室温以下为可流动的液体,而在人体温度时则转变成凝胶的新型药物控制释放载体材料。本研究采取溶液聚合法,经两步聚合,以聚乙二醇为中间链段,合成了含有对二氧六环酮结构单元的温敏型嵌段共聚物。通过1H-NMR、溶胶-凝胶转变实验手段对共聚物的化学组成和化学微结构、共聚物水溶液的溶胶-凝胶转变性能进行了表征。通过该研究获得了释药周期较小的新型可注射温敏型水凝胶,且该体系在降解过程中释放的酸性物质少,有利于保持药物的生物活性。

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    Biodegradable thermosensitive gels are a class of novel drug delivery carriers that are flowable liquid at room temperature but become solid gels at body temperature. In this thesis, a type of biodegradable thermogelling copolymers containing novel component or structural unit PDO were synthesized by solution polymerization with two-step olymerization. A combined techniques and experiments including 1H-NMR, degradation tests were employed to characterize the copolymers, investigate sol-gel transitions of the copolymer solutions and to investigate degradation and drug delivery properties of the gels. In conclusion, we have acquired a type of thermosensitive gels with suitable sol-to-gel transition temperatures that could be adsorbed in human body in aropriate time and will not produce a lot of acidic by-products during the degradation time. These thermosensitive gels are injectable with promising aplications as long-term drug delivery carriers, especially for acidic sensitive macromolecular drugs and hydrophobic drugs.

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黄国峰,尤玉静. 温敏型聚对二氧六环酮水凝胶的制备[J]. 科学技术与工程, 2011, (23): .
HUANG Guofeng, YOU Yujing. Synthesis of biodegradable thermo-sensitive gels of p-dioxanone[J]. Science Technology and Engineering,2011,(23).

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  • 收稿日期:2011-05-08
  • 最后修改日期:2011-05-23
  • 录用日期:2011-05-27
  • 在线发布日期: 2011-07-08
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