This paper describes a device driver without having to develop, through direct access to S3C2410 embedded system I / O port registers , realizes the multi-serial communication, Elaborated in detail realizes the process based on the Windows CE S3C2410 embedded system multi-serial port communication, given some source code, solve the complex development of device drivers is difficult and long problems. Method is simple and practical, stable and reliable data communications, has been applied in engineering practice ,can be directly transplanted into the similar system.