This thesis takes the guidance of multi-missile coordination as the background, and focused on the time and space coordination methods in the four-dimensional guidance and control. Based on the original three-dimensional problem, the time restriction was added to suit the four-dimensional guidance of multi-missile coordination. but the control of arrival time is strong related with the speed and flight path, After designing hight and speed decoupling controller, I designed the BTT missile coordinated circuit, the altimetric compensation circuit, the speed equalizing circuit, then completed a four-dimensional guidance control system and the overall design of the simulation study. The results of the simulation certified that the control system i designed can resolve time and space coordination synergy in multi-missile synergy operation.