The purpose of this study is investigated the impact of landscape layouts on the campus microclimate in northern Guangxi. In this paper, a field measurement on typical landscapes included waters, woodlands, grasslands and empty spaces of a campus is carried out. Based on the measured data, the differences between those landscapes in local microclimate are compared, and its effects on the thermal comfort of campus microclimate are analyzed by numerical simulation. The results show that: 1) the underlying surface texture of landscape types is the primary reason of local microclimate differences; 2) the thermal environment at the empty space is more comfortable and stable when compared to others; 3) The effect of grassland on creating microclimate environment and improving the spaces’ comfort is of significant. This research have certain reference significance for campus landscape design and campus microclimate research in northern Guangxi, and provide scientific basis for improving campus microclimate and the comfort of campus space.