In order to analyze the properties of E-51 epoxy resin adhesive modified by polyamide resin in detail, the research method of properties of E-51 epoxy resin adhesive modified by polyamide resin for building was proposed. This method tested the performance of E-51 epoxy resin adhesive modified by polyamide resin in building materials from two aspects of different polyamide resin content, different prepolymer ratio and content. The test results show that the content of polyamide resin is 10phr, and the viscosity will be increased to 100000 The results showed that the viscosity of the modified E-51 epoxy resin adhesive was significantly higher than that of the modified E-51 epoxy resin adhesive; the tensile strength and compressive strength of the modified E-51 epoxy resin adhesive decreased with the increase of polyamide content, and the shear strength value gradually increased; the performance of the modified E-51 epoxy resin adhesive was the best when diethylenetriamine and polyamide were mixed according to the ratio of 6.6:1.1 When the ratio of Oh: NCO is 1:3 and the content of prepolymer is 35phr, the shear strength and mechanical properties of E-51 epoxy resin adhesive modified by polyamide resin are the highest.